Addex Starts A Second Phase IIb Trial Of ADX10059 In GERD
Addex Pharmaceuticals (SWISS: ADXN), the allosteric modulation company, announced the start of a Phase IIb trial of ADX10059 monotherapy in patients with gastroesophageal reflux disease (GERD), the cause of heartburn and other symptoms. ADX10059 is a first-in- class reflux inhibitor that works by reducing activation of the metabotropic glutamate receptor 5 (mGluR5) through negative allosteric modulation (NAM).

Newly Discovered Esophagus Stem Cells Grow Into Transplantable Tissue
Researchers at the University of Pennsylvania School of Medicine have discovered stem cells in the esophagus of mice that were able to grow into tissue-like structures and when placed into immune-deficient mice were able to form parts of an esophagus lining. The investigators report their findings online this month in the Journal of Clinical Investigation.

December Highlighted Studies In The Journal CHEST
MEN WITH EMPHYSEMA AT RISK FOR OSTEOPOROSIS New research shows that men with chronic obstructive pulmonary disease (COPD), which includes emphysema and chronic bronchitis, may also be at risk for osteoporosis. Researchers from Japan performed chest CT scans and pulmonary function tests on 65 male patients with COPD.

Barrett's Esophagus May Be Affected By DFMO
"While there was a suggestion that DFMO may influence the extent of Barrett's dysplasia, this finding is very preliminary and further study of this agent in a larger number of patients is needed," said Frank A. Sinicrope, M.D., professor of medicine and oncology at the Mayo Clinic, Rochester, MN. Sinicrope presented his findings here at the American Association for Cancer Research's Seventh Annual International Conference on Frontiers in Cancer Prevention Research.

Esophageal Cancer: Be Aware Of The Early Warning Signs
According to the American Cancer Society (ACS), more than 16,000 new esophageal cancer cases are diagnosed each year in the U.S. Unfortunately the survival rate in these cases is only 10 percent. This alarming statistic is due largely to the fact that by the time the majority of cases are diagnosed, the cancerous tumors have grown to the point of inoperability.

Discoveries In Genetics, Stem Cell Therapies And New Treatments For Childhood Diseases Explored By World Community Of Pediatricians
On Nov. 8 and 9, Morgan Stanley Children's Hospital of NewYork-Presbyterian and Columbia University Medical Center hosted an "Innovations in Pediatric Medicine" conference at the Grand Hyatt New York, which featured lectures by international leading authorities in pediatric biomedical research, genetic findings and stem cell therapy breakthroughs.

Surgery Is Beneficial For Treatment Of Gastro-oesophageal Reflux
Research published by the National Institute for Health Research Health Technology Assessment (NIHR HTA) programme has found that early surgery is beneficial for patients with chronic symptoms of gastro-oesophageal reflux disease (GORD). Reflux is a very common condition with 20 per cent of the population experiencing it at some point in their lives.

Discovery Of Gene That Helps Control The Production Of Stomach Acid
University of Cincinnati (UC) researchers have discovered a gene that helps control the secretion of acid in the stomach - information that could one day aid scientists in creating more efficient treatment options for conditions such as acid reflux or peptic ulcers. This data is published in the Nov. 3 edition of the Proceedings of the National Academy of Sciences (PNAS).

A Bad Chain-link Reaction: How A Healthy Stomach Can Hurt You
There is a cancer in the United States that isn't sneaking up on us; it's already here. Cancer of the esophagus is one of just two cancers that are increasing in this country (skin cancer is the second) and the western world. In fact, figures from the National Cancer Institute show cancer of the esophagus has gone up 400 percent since 1975. And as the cancer spreads, its sufferers aren't who they used to be.

How To Tell If That Holiday Heartburn Is Something More Serious
For many people, Thanksgiving is about having family near and celebrating, sometimes in excess. That's because for some holiday revelers, perhaps the amount of time spent watching football on the tube is only surpassed by a second activity: eating.

Evidence-Based GERD Guidelines Released By The American Gastroenterological Association
Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal conditions seen in GI and primary care clinics, however physicians who treat the disease primarily rely on empirical trials of medications and their own observations and experience to manage their patients. Therefore, the American Gastroenterological Association (AGA) Institute has published evidence-based guidelines for the management and treatment of suspected GERD.

What Is The Relationship Between Laryngopharyngeal Reflux And Reflux Esophagitis?
The association between gastroesophageal reflux disease (GERD) and laryngeal disorders has been recognized since the late 1960s. Chronic laryngeal signs and symptoms associated GERD are often referred to as reflux laryngitis or laryngopharyngeal reflux (LPR). However, the cause-and-effect relationship between GERD and LPR still remains elusive.. A research article published in the World Journal of Gastroenterology addresses this question. The research team led by Dr.

Summer Is Peak Season For Diagnosis Of Esophagus Disorder According To New Study
Most people who experience chronic heartburn have symptoms that are caused by gastroesophageal reflux disease, or GERD. Two new studies presented at the 73rd Annual Scientific Meeting of the American College of Gastroenterology examined eosinophilic esophagitis (EoE), a condition that can mimic symptoms of GERD, in a small proportion of people. The first study found that the diagnosis of EoE, previously termed "allergic esophagitis," peaked during the summer months.

TAK-390MR Demonstrated Higher Healing Rates Compared To Lansoprazole As The Severity Of Erosive Esophagitis Grade Increased
Combined results from two Phase 3 studies presented at the American College of Gastroenterology Annual Scientific Meeting (ACG) in Orlando, Fla., demonstrated that TAK-390MR resulted in higher healing rates than lansoprazole among patients with more severe grades of erosive esophagitis (EE). TAK-390MR combines dexlansoprazole with a Dual Delayed Release™ (DDR) formulation, designed to provide two separate releases of drug for extended duration of acid suppression.

What Are The Clinical Features Of Ineffective Esophageal Motility?
Ineffective oesophageal motility (IOM) is a common swallowing abnormality characterised by low-amplitude contractile sequences in the lower oesophagus. These ineffective sequences include low amplitude but progressive, low-amplitude simultaneous, and non-transmitted contractile patterns.