Study Links Molecule To Muscle Maturation, Muscle CancerResearchers at The Ohio State University Comprehensive Cancer Center have discovered that a molecule implicated in leukemia and lung cancer is also important in muscle repair and in a muscle cancer that strikes mainly children. The study shows that immature muscle cells require the molecule, called miR-29, to become mature, and that the molecule is nearly missing in cells from rhabdomyosarcoma, a cancer caused by the proliferation of immature muscle cells.
Grape Seed Extract Kills Cancer Cells In LabA team of scientists from the US and China have discovered that grape-seed extract kills laboratory leukemia cells by making them commit suicide, thus showing the potential value of natural compounds in the treatment of cancer.
Paediatric Patient Treated Using RapidArc™ Radiotherapy Technology In SwitzerlandA Swiss cancer clinic is among the first in the world to use a new, faster radiotherapy technology from Varian Medical Systems (NYSE: VAR) to treat a child patient. A 12-year-old girl with Hodgkin's lymphoma was treated using Varian's RapidArc™ technique at the Oncology Institute of Southern Switzerland (IOSI) in Bellinzona.
FDA Approves Drug That Boosts Stem Cell Yield For Bone Marrow TransplantsThe U.S. Food and Drug Administration approved Mozobil (plerixafor), a drug that helps increase the number of blood stem cells for bone marrow transplantation in patients with certain forms of blood cancer. Mozobil is intended to be used in combination with the growth factor granulocyte-colony stimulating factor (G-CSF), for treatment of adults with multiple myeloma or non-Hodgkin's lymphomas.
Stem Cells And Leukemia Battle For Marrow MicroenvironmentLearning how leukemia takes over privileged "niches" within the bone marrow is helping researchers develop treatment strategies that could protect healthy blood-forming stem cells and improve the outcomes of bone marrow transplantation for leukemia and other types of cancer. In a paper in the journal Science, available early online Dec.
Preventing A Recurrence Of The Northwick Park TrialScientists investigating the 2006 Northwick Park drug-trial disaster that left six healthy volunteers hospitalised say they have developed new pre-clinical tests that could have stopped the trial from ever going ahead. But Dr Stephen Poole, speaking at the British Pharmacological Society's Winter Meeting in Brighton, said that research is still "ongoing" to understand why the drug had such an adverse effect in the clinic but not in pre-clinical testing.
One Step Closer To A Treatment For Mixed-Lineage LeukemiaInfants and adults with the blood cancer mixed-lineage leukemia (MLL) typically have a poor prognosis, and most infants die before their first birthdays. Although there are varying causes of MLL, most cases are caused by a fusion of two genes, the MLL and the AF4 genes. When the MLL gene is fused to the AF4 gene, a potent cancer-causing oncogene is created.
Genta To Appeal FDA Decision On New Drug Application For Genasense(R) In Patients With Chronic Lymphocytic LeukemiaGenta Incorporated (OTCBB: GNTA.OB) announced that the Company has filed an appeal of the recent negative decision by the Food and Drug Administration's (FDA) Office of Oncology Drug Products (OODP) regarding the Company's New Drug Application (NDA) for Genta's lead oncology product, Genasense® (oblimersen sodium) Injection. The NDA proposed the use of Genasense in combination with chemotherapy as treatment for patients with relapsed or refractory chronic lymphocytic leukemia (CLL).
An Enzyme That Mutates Antibodies Also Targets A Cancer-Causing OncogeneThe human immune system is in a perpetual state of self-experimentation. It expertly mutates and shuffles the DNA of its own cells to evolve new defenses against the vast array of microbes that try to invade our bodies. But when the genetic experiment goes awry, the result can be a deadly cancer.