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Toxicity Mechanism Identified For Parkinson's Disease
Neurologists have observed for decades that Lewy bodies, clumps of aggregated proteins inside cells, appear in the brains of patients with Parkinson's disease and other neurodegenerative diseases. The presence of Lewy bodies suggests underlying problems in protein recycling and waste disposal, leading to the puzzle: how does disrupting those processes kill brain cells? One possible answer: by breaking a survival circuit called MEF2D.
Parkinson's Disease Plays Havoc With Common Orthopaedic Conditions
Although Parkinson's disease (PD) is a neurological disorder, according to an article in the January 2009 issue of the Journal of the American Academy of Orthopaedic Surgeons, the disease also increases a person's risk of experiencing complicated orthopaedic conditions. The author recommends that all Parkinson's treatment plans include a multidisciplinary approach in order to address additional accompanying musculoskeletal health issues. According to the author Lee M.
Sleep Disorder May Be Early Sign Of Dementia Or Parkinson's Disease
People with a sleep disorder that causes them to kick or cry out during their sleep may be at greater risk of developing dementia or Parkinson's disease, according to a study published in the December 24, 2008, online issue of Neurology®, the medical journal of the American Academy of Neurology. The sleep disorder is called REM sleep behavior disorder.
Immune Cells Contribute To The Development Of Parkinson's Disease
Parkinson disease is a neurodegenerative disorder that impairs movement, balance, speech, and other functions. It is characterized by the loss of nerves in the brain that produce a substance known as dopamine. Although the loss of dopamine-containing nerves is accompanied by accumulation of immune cells known as T cells, these accumulating T cells were not thought to have a role in the development of disease. However, Stéphane Hunot, Etienne C.
New 'Smart' Materials For The Brain
Research done by scientists in Italy and Switzerland has shown that carbon nanotubes may be the ideal "smart" brain material. Their results, published in the advance online edition of the journal Nature Nanotechnology, are a promising step forward in the search to find ways to "bypass" faulty brain wiring. The research shows that carbon nanotubes, which, like neurons, are highly electrically conductive, form extremely tight contacts with neuronal cell membranes.
Immune Cells Implicated In Parkinson's Disease
Scientists in France and the US discovered that a type of immune system cell may facilitate the development of Parkinson's Disease and that targetting part of the immune system with drugs could be a new way to treat the disease.
Cellular Reprogramming: Science's Breakthrough Of The Year
In its annual list of the year's top ten scientific breakthroughs, the journal Science has given top honors to research that produced "made-to-order" cell lines by reprogramming cells from ill patients. These cell lines, and the techniques for producing them, offer long-sought tools for understanding -- and hopefully someday curing -- difficult-to-study diseases such as Parkinson's disease and type 1 diabetes.
'Molecular Manual' For 100s Of Inherited Diseases Compiled By Researchers
An international research team has compiled the first catalogue of tissue-specific pathologies underlying hundreds of inherited diseases. These results provide information that may help treat conditions such as breast cancer, Parkinson's disease, heart disease and autism. The report from scientists at the Technical University of Denmark and Massachusetts General Hospital (MGH) will appear in the Proceedings of the National Academy of Sciences and has been published online.
Are Older Antidepressants Better For Depression In Parkinson's Disease?
A new study shows that antidepressant drugs which only affect serotonin, often used as first choice treatments, may not be best for depression in people with Parkinson's disease. The new research is published in the December 17, 2008, online issue of Neurology®, the medical journal of the American Academy of Neurology. Depression affects up to 50 percent of people with Parkinson's disease.
Using A Single Virus To Convert Adult Cells To Embryonic Stem Cell-Like Cells
Whitehead Institute researchers have greatly simplified the creation of so-called induced pluripotent stem (iPS) cells, cutting the number of viruses used in the reprogramming process from four to one. Scientists hope that these embryonic stem-cell-like cells could eventually be used to treat such ailments as Parkinson's disease and diabetes.
Old Tennis Balls Help Parkinson's Disease Patients At Nottingham Hospitals Trust
Hundreds of patients in Nottingham are benefitting from an almost unlimited supply of free tennis balls to help with exercises to control the often debilitating symptoms of Parkinson's disease. The tennis balls are being donated by the Nottingham Tennis Centre after they were approached and asked to help by Nottingham University Hospitals NHS Trust's physiotherapist, Sandy Gill.
Preclinical Studies Suggest That Living Cell Technologies' NeurotrophinCell Is Effective In Parkinson's Disease
Living Cell Technologies Limited (ASX: LCT; OTCQX: LVCLY) today reported that its pipeline product, NeurotrophinCell (NtCell), encapsulated brain choroid plexus cells, may be beneficial in Parkinson's disease. In preclinical studies, rats with induced Parkinson's disease showed improved limb function and significantly more surviving brain cells after they received implants of NtCell. LCT is now evaluating NtCell for other brain diseases.
Patients And Caregivers Unprepared For The Mental And Behavioral Changes Associated With Parkinson's Disease
Parkinson's disease affects 6.3 million people worldwide. While the disease is recognized for its profound effects on movement, up to 40 percent of Parkinson's disease patients also develop changes in thought, behavior and judgment. As Parkinson's disease progresses, patients may experience what is called 'Parkinson's Psychosis,' in which they experience changes in thought, behavior and judgment.
Onset Of Parkinson's Disease May Be Signalled By A Fading Sense Of Smell
Many individuals with Parkinson's disease are able to recall losing their sense of smell well before the onset of more commonly recognized symptoms such as tremors, impaired dexterity, speech problems, memory loss and decreased cognitive ability.
Affiris Begins Development Of A Parkinson's Vaccine
AFFiRiS has started pre-clinical development of a Parkinson¹s vaccine. The vaccine, known as PD01, can be used to target a specific protein that is closely associated with the causes of this degenerative neurological disease. Excellent product candidates from discovery studies have prompted the company to file a patent application and proceed immediately with development.
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