Toxicity Mechanism Identified For Parkinson's DiseaseNeurologists have observed for decades that Lewy bodies, clumps of aggregated proteins inside cells, appear in the brains of patients with Parkinson's disease and other neurodegenerative diseases. The presence of Lewy bodies suggests underlying problems in protein recycling and waste disposal, leading to the puzzle: how does disrupting those processes kill brain cells? One possible answer: by breaking a survival circuit called MEF2D.
Parkinson's Disease Plays Havoc With Common Orthopaedic ConditionsAlthough Parkinson's disease (PD) is a neurological disorder, according to an article in the January 2009 issue of the Journal of the American Academy of Orthopaedic Surgeons, the disease also increases a person's risk of experiencing complicated orthopaedic conditions. The author recommends that all Parkinson's treatment plans include a multidisciplinary approach in order to address additional accompanying musculoskeletal health issues. According to the author Lee M.
Sleep Disorder May Be Early Sign Of Dementia Or Parkinson's DiseasePeople with a sleep disorder that causes them to kick or cry out during their sleep may be at greater risk of developing dementia or Parkinson's disease, according to a study published in the December 24, 2008, online issue of Neurology®, the medical journal of the American Academy of Neurology. The sleep disorder is called REM sleep behavior disorder.
Immune Cells Contribute To The Development Of Parkinson's Disease Parkinson disease is a neurodegenerative disorder that impairs movement, balance, speech, and other functions. It is characterized by the loss of nerves in the brain that produce a substance known as dopamine. Although the loss of dopamine-containing nerves is accompanied by accumulation of immune cells known as T cells, these accumulating T cells were not thought to have a role in the development of disease. However, Stéphane Hunot, Etienne C.
New 'Smart' Materials For The BrainResearch done by scientists in Italy and Switzerland has shown that carbon nanotubes may be the ideal "smart" brain material. Their results, published in the advance online edition of the journal Nature Nanotechnology, are a promising step forward in the search to find ways to "bypass" faulty brain wiring. The research shows that carbon nanotubes, which, like neurons, are highly electrically conductive, form extremely tight contacts with neuronal cell membranes.
Immune Cells Implicated In Parkinson's DiseaseScientists in France and the US discovered that a type of immune system cell may facilitate the development of Parkinson's Disease and that targetting part of the immune system with drugs could be a new way to treat the disease.
Cellular Reprogramming: Science's Breakthrough Of The YearIn its annual list of the year's top ten scientific breakthroughs, the journal Science has given top honors to research that produced "made-to-order" cell lines by reprogramming cells from ill patients. These cell lines, and the techniques for producing them, offer long-sought tools for understanding -- and hopefully someday curing -- difficult-to-study diseases such as Parkinson's disease and type 1 diabetes.
'Molecular Manual' For 100s Of Inherited Diseases Compiled By ResearchersAn international research team has compiled the first catalogue of tissue-specific pathologies underlying hundreds of inherited diseases. These results provide information that may help treat conditions such as breast cancer, Parkinson's disease, heart disease and autism. The report from scientists at the Technical University of Denmark and Massachusetts General Hospital (MGH) will appear in the Proceedings of the National Academy of Sciences and has been published online.
Are Older Antidepressants Better For Depression In Parkinson's Disease?A new study shows that antidepressant drugs which only affect serotonin, often used as first choice treatments, may not be best for depression in people with Parkinson's disease. The new research is published in the December 17, 2008, online issue of Neurology®, the medical journal of the American Academy of Neurology. Depression affects up to 50 percent of people with Parkinson's disease.
Using A Single Virus To Convert Adult Cells To Embryonic Stem Cell-Like CellsWhitehead Institute researchers have greatly simplified the creation of so-called induced pluripotent stem (iPS) cells, cutting the number of viruses used in the reprogramming process from four to one. Scientists hope that these embryonic stem-cell-like cells could eventually be used to treat such ailments as Parkinson's disease and diabetes.
Old Tennis Balls Help Parkinson's Disease Patients At Nottingham Hospitals TrustHundreds of patients in Nottingham are benefitting from an almost unlimited supply of free tennis balls to help with exercises to control the often debilitating symptoms of Parkinson's disease. The tennis balls are being donated by the Nottingham Tennis Centre after they were approached and asked to help by Nottingham University Hospitals NHS Trust's physiotherapist, Sandy Gill.
Affiris Begins Development Of A Parkinson's VaccineAFFiRiS has started pre-clinical development of a Parkinson¹s vaccine. The vaccine, known as PD01, can be used to target a specific protein that is closely associated with the causes of this degenerative neurological disease. Excellent product candidates from discovery studies have prompted the company to file a patent application and proceed immediately with development.