New Congenital Neutropenia Syndrome And Causative Gene Mutation Identified By Scientists A team of scientists has discovered a new syndrome associated with severe congenital neutropenia (SCN), a rare disorder in which children lack sufficient infection-fighting white cells, and identified the genetic cause of the syndrome: mutations in the gene Glucose-6-phosphatase, catalytic subunit 3 (G6PC3). The findings, which are published in the Jan.
Discovery Could Improve Understanding Of Ulcerative Colitis, Lead To New TherapiesAn international team led by University of Pittsburgh School of Medicine researchers has identified genetic markers associated with risk for ulcerative colitis. The findings, which appear as an advance online publication of the journal Nature Genetics, bring researchers closer to understanding the biological pathways involved in the disease and may lead to the development of new treatments that specifically target them.
New Device Couples, Fuses Cells For Stem Cell ResearchMIT engineers have developed a new, highly efficient way to pair up cells so they can be fused together into a hybrid cell. The new technique should make it much easier for scientists to study what happens when two cells are combined. For example, fusing an adult cell and an embryonic stem cell allows researchers to study the genetic reprogramming that occurs in such hybrids.
Dormant Cancer Cells Rely On Cellular Self Cannibalization To SurviveA single tumor-suppressing gene is a key to understanding, and perhaps killing, dormant ovarian cancer cells that persist after initial treatment only to reawaken years later, researchers at The University of Texas M. D. Anderson Cancer Center report in the December Journal of Clinical Investigation. The team found that expression of a gene called ARHI acts as a switch for autophagy, or self-cannibalization, in ovarian cancer cells.
In Lung Cancer, Silencing One Crucial Gene Disrupts Normal Functioning Of GenomeWhile examining patterns of DNA modification in lung cancer, a team of international researchers has discovered what they say is a surprising new mechanism. They say that "silencing" of a single gene in lung cancer led to a general impairment in genome-wide changes in cells, contributing to cancer development and progression.
Gene Therapy Reversed Heart Damage In Heart FailureLong-term gene therapy resulted in improved cardiac function and reversed deterioration of the heart in rats with heart failure, according to a recent study conducted by researchers at Thomas Jefferson University's Center for Translational Medicine. The study was published online in Circulation.
"Mitochondrial Dysfunction In Neurological Diseases" 6th Meeting In "Emergence & Convergence" SeriesLa Fondation Ipsen and Nature Publishing Group share the same desire to help new scientific knowledge emerge and facilitate the exchange of the most promising ideas from a variety of different research areas. In 2007, the two organisations came together to create a new series of scientific events - the Emergence & Convergence mini-symposia - one-day meetings highlighting some of the most dynamic sectors in biological and medical research.
Safe New Therapy For Genetic Heart Disease A new clinical trial suggests that long-term use of candesartan, a drug currently used to treat hypertension, may significantly reduce the symptoms of genetic heart disease. The related report by Penicka et al, "The effects of candesartan on left ventricular hypertrophy and function in non-obstructive hypertrophic cardiomyopathy: a pilot, randomized study," appears in the January issue of The Journal of Molecular Diagnostics.
Scientists Isolate Genes That Made 1918 Flu LethalBy mixing and matching a contemporary flu virus with the "Spanish flu" a virus that killed between 20 and 50 million people 90 years ago in history's most devastating outbreak of infectious disease researchers have identified a set of three genes that helped underpin the extraordinary virulence of the 1918 virus.
Invitrogen Launches Solutions To Simplify DNA And RNA Workflows On Next-Generation Sequencing SystemsInvitrogen, part of Life Technologies Corporation (NASDAQ: LIFE), a provider of innovative life science solutions, today announced the introduction of two reagent solutions to simplify genomic and transcriptome analysis on next-generation, high-throughput genomic analysis platforms. Both solutions provide basic and clinical researchers with an innovative workflow that greatly reduces the time, cost, and experimental variability associated with next-generation sequencing library preparation.
How Much Do Genetic Covariances Alter The Rate Of Adaptation?Organisms are composed of suites of correlated traits. If these traits have a shared genetic basis, these relationships can influence their evolution. While this possibility is well known, it remains unclear how commonly genetic relationships between traits affects their evolution in nature. Here we introduce a new metric for quantifying whether the relationships between traits affects the rate of adaptation, and evaluate it using data from the literature.