Participants In Clinical Trials Should Be Viewed As Partners In ResearchWhile an estimated 2.3 million people in the United States take part in clinical trials every year, there currently exists no formal requirement to inform them of study results, an oversight that leaves participants confused, frustrated, and, in some cases, lacking information that may be important to their health.
Novel Histone Demethylase Protein Complex Discovered By Researchers At Stowers Institute's Workman LabThe Stowers Institute's Workman Lab has discovered a novel histone demethylase protein complex characterized in work published in Molecular Cell. The Histone H3 protein is an important component of chromatin, the packing material wrapping up chromosomal DNA and preventing unwanted transcription of the message encoded in the DNA. Histone H3 can be altered by adding (methylating) or removing (demethylating) methyl groups from the histone protein.
'Deranged Calcium Signaling' Contributes To Neurological Disorder, UT Southwestern Researchers FindDefective calcium metabolism in nerve cells may play a major role in a fatal genetic neurological disorder that resembles Huntington's disease, researchers at UT Southwestern Medical Center have found in a mouse study. The disease, called spinocerebellar ataxia 3 - also known as SCA3, or Machado-Joseph disease - is a genetic disorder that, like Huntington's, impairs coordination, speech, and vision and causes brain atrophy.
New Clue Emerges For Cellular Damage In Huntington's Disease"Huntington's disease presents an ideal vantage point to study neurodegenerative disease, because we know the misfolded protein that's responsible," says Martin Duennwald, formerly a postdoctoral researcher in the lab of Whitehead Member Susan Lindquist. "But we don't understand how this protein causes cellular damage and death for the neurons that are affected.
Antioxidants Could Help Huntington's Disease SufferersTherapeutic strategies to strengthen antioxidant defences could help to prevent the progression of Huntington's Disease. This is the suggestion from the results of the first ever trial on human samples carried out by researchers at the University of Lleida. The results have been published in the latest issue of Free Radical Biology & Medicine magazine.
Structure Of Important Neurological Receptor Defined By Scripps Research ScientistsFindings establish a platform to understand G protein-coupled receptors; may help in development of new class of Parkinson's treatments Scientists from The Scripps Research Institute have determined the structure of an adenosine receptor that plays a critical role in a number of important physiological processes including pain, breathing, and heart function.
Compounds That Prevent Nerve Damage Discovered By Duke TeamDuke University Medical Center scientists have made a significant finding that could lead to better drugs for several degenerative diseases including Huntington's disease and Alzheimer's disease. Compounds that block the activity of a specific enzyme prevented brain injury and greatly improved survival in fruit flies that had the same disease process found in Huntington's disease.
News Tips From The Journal Of Neuroscience PCP2 Shapes Light Response of ON Bipolar Cells Ying Xu, Pyroja Sulaiman, Rod Feddersen, Jian Liu, Robert G. Smith, and Noga Vardi Activation of G-protein-coupled receptors (e.g., metabotropic glutamate receptors in retinal ON bipolar cells) causes GTP to bind to the G-protein in place of GDP, resulting in dissociation and activation of Gα and Gβγ subunits and subsequent downstream effects (e.g., closing of cation channels).
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